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In the context of Everolimus & Renal cell carcinoma (RCC), Everolimus received FDA approval in 2009 for advanced/metastatic Renal cell carcinoma (RCC) that has progressed after treatment with sunitinib or sorafenib, based on the phase III RECORD‑1 trial showing improved progression‑free survival versus placebo (1). It is positioned as therapy after failure of VEGF‑receptor tyrosine kinase inhibitors and has more recently shifted toward later‑line use because newer agents ([cabozantinib](brain://AAEE1EJv0FWZnttN1YNr-A/C…