Cellular metabolism & Immune Response

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Cellular metabolism serves a crucial function in regulating immune responses
Buck et al. 2017 Cell 169(4): 570–86
O’Sullivan et al. 2019 Nat Rev Immunol. 19(5): 324–35

Immunosuppressive cells, such as regulatory T (Treg) cells, have a symbiotic metabolic relationship with cancer cells
Wang et al. 2018 Mol Cancer 17(1):168

Cancer cells exhibit an enhanced ability to obtain nutrients, which increases the possibility of restricting nutrient consumption by TILs, thereby inducing T-cell exhaustion and immune escape
Chang et al. 2015 Cell 162(6):1229–41

see also:
[Immunomodulation & Tumor Microenvironment (TME)](brain://S3ua2JtnvEWRU1p7Ed5qYg/Immunomodul…

References (Sources)

Effects of tumor metabolic microenvironment on regulatory T cells
Wang et al. 2018j Mol Cancer 17(1): 168
Review
Metabolic competition in the tumor microenvironment is a driver of cancer progression
Chang et al. 2015 Cell 162(6):1229–41
Metabolic instruction of immunity
Buck et al. 2017 Cell 169(4): 570–86
Review
Metabolic interventions in the immune response to cancer
O’Sullivan et al. 2019 Nat Rev Immunol. 19(5): 324–35

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Cellular metabolism & Immune Response

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