Bile acids / Bile salts & Biosynthesis

What is the hepatic synthesis of bile acids from cholesterol?
De novo bile acid synthesis occurs in the liver, predominantly in pericentral or perivenous hepatocytes. Bile acid formation is the major pathway for cholesterol elimination from the body (1, 2). The hydrophobic ring structure of the cholesterol is digested into more water-soluble amphipathic compounds
Lefebvre et al. 2009 Physiol. Rev. 89: 147-191

What are the major pathways carry out Bile acid synthesis?

In the liver, two major pathways carry out Bile acid synthesis / Bile acid biosynthesis, the classic (initiated by CYP7A1) and the alternative pathway (initiated by [Sterol 27-hydroxyla…