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Cholestatic liver disease (CLD) is a prevalent liver disorder that has few treatment options available.
Zinc (Zn) supplementation has the potential to modify the gut microbiota, which can help reduce cholestatic liver injury. In both mice and humans, oral Zn changed the microbiota composition. A human study, registered at clinicaltrials.gov under NCT05597137, showed an increase in the abundance of Blautia producta (B. producta) and facilitated the production of p-coumaric acid.
The concentrations of [p-coumaric…