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ATP Is Actively Secreted by a Subset of Intestinal Bacteria
Via the ionotropic P2X7 receptor, ATP regulates the amount of follicular helper T cells (Tfh) in the Peyer's patches (PPs) of the small intestine
P2X7-deficient Tfh cells show increased IgA secretion and its binding to commensal bacteria.
ATP released by commensals limits the secretory IgA response in the small intestine
Perruzza et al. 2017 Cel…