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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Cell Surface Sialylation

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Most Glycoproteins and Glycolipids (GIPLs) are terminally modified by sialylation to sialylglycans, significantly affecting normal immune system function.
Lowe 2001 Cell 104: 809
Rudd et al. 2001

Regulated homing function is lost. Abnormal immune system activation occurs, leading to autoimmunity
Ellies et al. 1998 Immunity 9: 881
Demetriou et al. 2001 Nature 409: 733-9

Sialylglycans can confer regulatory potential to T cells. For example, genetic disruption of the normal N-glycosylation pathway promo…

References (Sources)

Alteration of Cell Surface Sialylation Regulates Antigen-Induced Naive CD8+ T Cell Responses
Pappu & Shrikant 2004 J Immunol 173: 275-284
Branched O-linked oligosaccharides ectopically expressed in transgenic mice reduce primary T-cell immune responses
Tsuboi & Fukuda 1997 EMBO J. 16: 6364
Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inﬂammation
Ellies et al. 1998 Immunity 9: 881
Glycosylation and the Immune System
Rudd et al. 2001
Review
Glycosylation, immunity and autoimmunity
Lowe 2001 Cell 104: 809
Review
Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation
Demetriou et al. 2001 Nature 409: 733-9

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Cell Surface Sialylation

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