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Medical Research Finder

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Myosin Light-Chain Kinase 1 (MLCK1)

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Myosin Light-Chain Kinase 1 (MLCK1) is also known to regulate the intestinal TJ barrier function via phosphorylation of myosin II regulatory light chain (MLC) at threonine-18 and/or serine-19 leading to peri-junctional actomyosin ring contraction, mechanical retraction of apical membrane and pulling apart of the TJ complex, and opening of the intestinal TJ barrier
Turner et al. 1999 Am J Physiol 277(3): C554-62
Ma et al. 2000 Am J Physiol Gastrointest Liver Physi…

A Membrane-Permeant Peptide That Inhibits MLC Kinase Restores Barrier Function in In Vitro Models of Intestinal Disease
Zolotarevsky et al. 2002 Gastroenterology 123(1): 163-72
Contributions of Myosin Light Chain Kinase to Regulation of Epithelial Paracellular Permeability and Mucosal Homeostasis
He et al. 2020a Int J Mol Sci 21(3): 1-17
Cytochalasin B Modulation of Caco-2 Tight Junction Barrier: Role of Myosin Light Chain Kinase
Ma et al. 2000 Am J Physiol Gastrointest Liver Physiol 279(5): G875-85
PKC-Dependent Regulation of Transepithelial Resistance: Roles of MLC and MLC Kinase
Turner et al. 1999 Am J Physiol 277(3): C554-62

7/2/2026