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Treatment strategies involve intensive chemotherapy (CTR), surgical resection, high dose CTR with hematopoietic stem cell support, radiotherapy, biotherapy, and immunotherapy with Anti-ganglioside 2 monoclonal antibodies.
Although high risk NBL is now better characterized and aggressive multimodal therapy is applied, the treatment outcomes are still poor, with overall survival and event-free survival of approximately 40% and 30% at 3-years, respectively.
The s…