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The lineage model posits that B-1 cells develop primarily in the fetal liver, and reside in serosal cavities, but can migrate to the spleen, bone marrow, and adipose tissue. In these supportive niches, they produce predominantly IgM antibodies in a T-cell–independent manner. The diversification and CXCR4-dependent establishment of the bone marrow B-1a cell pool govern the production of atheroprotective IgM, which is linked to human coronary atherosclerosis.
Alugupalli & Gerstein 2005 Immunity 2…