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The sympathoadrenal-medullary axis (SAM) is part of the autonomic nervous system. It is a crucial component of the body's stress response system and works in conjunction with the Hypothalamic–pituitary–adrenal axis (HPA axis).
The Sympathoadrenal medullary (SAM) axis is essential in the body's "fight or flight" response. Stress triggers the release of catecholamines, primarily epinephrine (adrenaline) and norepinephrine (noradrenaline), from the adrenal medulla.
The Sympathoadrenal medullary (S…