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Paromomycin is FDA approved for the treatment of intestinal amoebiasis (caused by Entamoeba histolytica). It is used as a luminal agent to eliminate cysts and prevent recurrence after initial treatment with a tissue-acting agent like metronidazole. Clinical guidelines and reviews recognize Paromomycin for this approved use in both the United States and Europe, and it is listed among standard agents for non-invasive (luminal) forms of the disease (1)
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