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Ibezapolstat inhibits bacterial DNA polymerase IIIC (Pol IIIC), a family of prokaryotic DNA polymerases. Pol IIIC is essential for DNA replication in low G+C Gram-positive bacteria, especially in the Firmicutes phylum, including Clostridioides difficile. By inhibiting Pol IIIC, ibezapolstat disrupts DNA synthesis, stopping bacterial growth and eliminating the pathogen.
Ibezapolstat is a non-absorbable antibiotic, concentrating in the [colon](brai…