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Glucocorticoids, particularly dexamethasone, have long been a cornerstone in the treatment of multiple myeloma. They are frequently combined with immunomodulatory drugs (IMiDs) such as thalidomide, lenalidomide, and pomalidomide. This combination enhances the depth of response and serves as the foundation for many standard doublet and triplet regimens used in both newly diagnosed and relapsed cases of the disea…