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Medical Research Finder

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

CD39 (Ectonucleoside Triphosphate Diphosphohydrolase-1 (ENTPD1))

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CD39 is an ectonucleotidase enzyme that hydrolyzes extracellular ATP to AMP, which is then converted to adenosine by CD73. Adenosine is a potent immunosuppressive molecule that inhibits anti-tumor immune responses.

CD39 is overexpressed on various immune cells (regulatory T cells, myeloid-derived suppressor cells) and tumor cells in the TME, leading to ex…

Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade
Yang et al. 2020c
Ecto-ATPase activity in cytolytic T-lymphocytes. Protection from the cytolytic effects of extracellular ATP
Filippini et al. 1990 J Biol Chem 265: 334–340
Ecto-enzyme and signaling functions of lymphocyte CD73
Resta et al. 1998 Immunol Rev 161: 95-109
Review
Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine
Kusu et al. 2013 J. Immunol. 190: 774–783
Role of extracellular ATP and P1 and P2 classes of purinergic receptors in T-cell development and cytotoxic T lymphocyte effector functions
Apasov et al. 1995 Immunol Rev 146: 5–19
Review
Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inﬂammasome-Driven Tumor Immunity
Li et al. 2019k Cancer Discovery 9: 1754

7/1/2026