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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Fucosyl-GM1 (FucGM1)

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Fucosyl-GM1 (FucGM1) is a monosialoganglioside that is highly expressed on the surface of small cell lung cancer (SCLC) cells, but has limited expression in normal tissues
Chu et al. 2022 JTO Clin Res Rep. 3(11): 100400

It is considered a tumor-associated antigen due to its prevalence in a large percentage of human Small-cell-lung-cancer (SCLC)
Ponath et al. 2018 Clin Cancer Res. 24(20): 5178-5189
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References (Sources)

A Novel, Fully Human Anti-fucosyl-GM1 Antibody Demonstrates Potent In Vitro and In Vivo Antitumor Activity in Preclinical Models of Small Cell Lung Cancer
Ponath et al. 2018 Clin Cancer Res. 24(20): 5178-5189
BMS-986012, an Anti-Fucosyl-GM1 Monoclonal Antibody as Monotherapy or in Combination With Nivolumab in Relapsed/Refractory SCLC: Results From a First-in-Human Phase 1/2 Study
Chu et al. 2022 JTO Clin Res Rep. 3(11): 100400

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Fucosyl-GM1 (FucGM1)

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