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A 2013 Cochrane review found that fluphenazine's was an imperfect treatment and other inexpensive drugs less associated with side effects may be an just as good in people with schizophrenia
Fluphenazine acts primarily by blocking post-synaptic dopaminergic D2 receptors in the basal ganglia, cortical and limbic system. It also blocks alfa1 adrenergic receptors, muscarinic M1 receptors, and [histaminergic H1 receptors](brain://bEpAXEjeikWOc8pi2tSZ6w/HistamineH1ReceptorA…