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Gastric dysbiosis, notably higher Methylobacterium abundance, is associated with decreased CD8 + tissue-resident memory T cells (TRMs).
This results in gastric cancer immune evasion and poor prognosis, suggesting Methylobacterium may play a role in gastric carcinogenesis.
TGF beta was significantly reduced in gastric cancer samples with a higher abundance of Methylobacterium
Methylobacterium can decrease TGF beta expression and CD8+ TRM cells in the tumor by establishing a mouse model of primary gastric …