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Cyclin-dependent kinase 4 (CDK4) inhibitors + Cyclin-dependent kinase 6 (CDK6) inhibitors (cdk4/6 inhibitors) are a class of drugs that target the cyclin-dependent kinases 4 and Cyclin-dependent kinase 6 (CDK6), which are crucial regulators of the cell cycle. These kinases, when complexed with their cyclin partners (particularly Cyclin D), play a pivotal role in driving the transition from the G1 phase to the S phase of the cell cycle, thereby promoting cell division and proliferation.
When the cyclin D/CDK complex is turned on by estrogen signals, using …