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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Biological effects / Functions / Functions & Trimethylamine-N-Oxide (TMAO)

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Contents

Concerning arteriosclerosis:

It promotes the accumulation of cholesterol in macrophages, which leads to the formation of foam cells and plaque formation in the arteries.

Trimethylamine-N-Oxide (TMAO) also induces endothelial dysfunction by impairing endothelial cell function and promoting inflammation.
Velasquez et al. 2016 Toxins (Basel) 8(11): 326
Zheng & He 2022 Curr Vasc Pharmacol. 20(1): 29-36
Canyelles et al. 2023 Int J Mol Sci. 24(3): 1940
Zhen et al. 2023 Front. Endocrinol. 14: 1085041

Trimethylamine-N-Oxide (TMAO) is a pro-atherogenic and pro-inﬂammatory compound because it promotes vascular inflammation through signaling of [mitogen-activated protein kinase (MAPK)](brain://LUFQTX-SNEOyKL97W5…

References (Sources)

Contribution of Trimethylamine N-Oxide (TMAO) to Chronic Inflammatory and Degenerative Diseases
Constantino-Jonapa et al. 2023 Biomedicines 11: 431
Review
Gut Microbiota- Dependent Marker TMAO in Promoting Cardiovascular Disease: Inflammation Mechanism, Clinical Prognostic, and Potential as a Therapeutic Target
Yang et al. 2019e Front. Pharmacol. 10: 1360
Review
Gut Microbiota-Derived TMAO: A Causal Factor Promoting Atherosclerotic Cardiovascular Disease?
Canyelles et al. 2023 Int J Mol Sci. 24(3): 1940
Review
Implications of trimethylamine N-oxide (TMAO) and Betaine in Human Health: Beyond Being Osmoprotective Compounds
Ilyas et al. 2022 Front. Mol. Biosci. 9: 964624
Review
The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases
Zhen et al. 2023 Front. Endocrinol. 14: 1085041
Review
Trimethylamine N-Oxide: The Good, the Bad and the Unknown
Velasquez et al. 2016 Toxins (Basel) 8(11): 326
Review
Trimethylamine-N- Oxide Pathway: A Potential Target for the Treatment of MAFLD
Li et al. 2021y Front. Mol. Biosci. 8: 733507
Review

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