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Tivozanib is a selective inhibitor of all three Vascular endothelial growth factor receptor (VEGFR) tyrosine kinases (VEGFR-1 / VEGFR tyrosine kinase-1, VEGFR-2 / VEGFR tyrosine kinase-2, VEGFR-3 / VEGFR tyrosine kinase-3), with limited off-target interaction, which demonstrates efficacy with improved tolerability relative to multikinase VEGFR-TKIs.
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