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Interleukin-27 (IL-27) has been identified as a critical regulator of thermogenesis in adipose tissue. It promotes the expression of thermogenic genes, such as uncoupling protein 1 (UCP1), in brown and beige adipose tissue
The effects of Interleukin-27 (IL-27) on thermogenesis appear to be independent of the traditional IL-27 receptor pathway. Studies in Interleukin 27 receptor, alfa subunit (IL-27R alfa) deficient mouse models have shown that IL-27 can directly activate thermogenic programs in adipose tissue, leading to increased [energy ex…