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Excessive alcohol abuse (Et-OH) exerts a direct detrimental effect on the intestinal barrier integrity by affecting the tight junction protein (i.e., zonula occludens 1 (ZO-1)) expression and a mucus layer. Physiologically, mucus (Muc2) is produced by the goblet cells. Instead, the Paneth cells (immune cells) secrete antimicrobial peptides (i.e., c-lectin [Reg3b/g](brain://hpozZuSkLE6V7cvwb74ULQ/RegeneratingIsletderivedProtei…