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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Antidepressant + Probiotics (living agents) & Major depressive disorder / Major Depression / Depressive episode (MDD)

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Contents

Probiotics seem to be effective in reducing depressive symptoms when administered in addition to antidepressants.
Gawlik-Kotelnicka & Strzelecki 2021 Pharmaceuticals 14: 384

Clinical data

Bifidobacterium animalis lactis + Bifidobacterium breve + Bifidobacterium longum + Lacticaseibacillus paracasei + Lactiplantibacillus plantarum + Lactobacillus acidophilus + Lactobacillus delbrueckii bulgaricus + Streptococcus thermophilus & Major depressive disorder / Major Depression / Depressive episode (MDD)

An add-on these probiotics can alleviate depressive symptoms, as measured by the Hamilton Depression Rating Scale (HAM-D). This improvement is accompanied by changes in both the gut microbiota and brain, undersc…

References (Sources)

Clinical, gut microbial and neural effects of a probiotic add-on therapy in depressed patients: a randomized controlled trial
Schaub et al. 2022 Transl Psychiatry 12: 227
Effects of Probiotics as Adjunctive Therapy to Fluoxetine on Depression Severity and Serum Brain-Derived Neurotrophic Factor, Cortisol, and Adrenocorticotropic Hormone in Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial
Elahinejad et al. 2025 Food Sci Nutr 13(4): e4698
Probiotic lactobacillus plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: A double-blind, randomized, placebo controlled study
Rudzki et al. 2019 Psychoneuroendocrinology 100: 213-222
Probiotics as a Treatment for “Metabolic Depression”? A Rationale for Future Studie
Gawlik-Kotelnicka & Strzelecki 2021 Pharmaceuticals 14: 384

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7/1/2026

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