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Ahmed et al. 2013 Int J Surg 11(10): 1131-6 published the results of a synbiotics preparation for a month and then “crossed over” to receive a placebo, or alternatively to receive the placebo first followed in the second month by synbiotic to patients with Crohn’s disease from a pilot trial with 8 subjects.
The authors' conclusion was: This study suggests that there is no difference in colonic microflora between patients with Crohn’s disease and that the spectrum of bacteria was not altered by synbiotic administration
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