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Stimulator of interferon genes (STING) links innate immunity to biological processes ranging from antitumor immunity to microbiome homeostasis.
First-generation STING (Stimulator of interferon genes) agonists are cyclic dinucleotide (CDN) analogs of cyclic guanosine monophosphate–adenosine monophosphate (cGAMP). When administered systemically in animal models, they induce inflammatory cytokines equipotently in tumor and normal tissues, owing to ubiquitous STING (Stimulator of interferon genes) expression.
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