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Osteoarthritis is the most common form of arthritis and the most common type of joint disease and can be thought of as a degenerative disorder with inflammatory components. It is a prevalent musculoskeletal disease (1, 2, 3).
It is linked to mechanical stress and structural damage. Subchondral bone remodeling is involved.Inflammation of the synovial membrane occurs (1).
New evidence shows immune imbalance and low-grade inflammation are key in OA's initiation and progression. Interstitial collagenases play a key role in OA. Specific enzy…