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Double-blind, placebo-controlled clinical trial to test whether Lactobacillus gasseri TMC0356 can modify the immune response in the elderly. Heat-killed TMC0356 or placebo was orally administered to 28 healthy subjects aged 50-70 years old for 4 weeks
Outcome measures:
Number of T cells, CD8+CD28+ cells, native T cells, B cells, natural killer (NK) cells, the ratios of CD4/CD8 T cells and native/memory T cells. NK cell activation and concanavalin A-induced lymphocyte transformation of the isolated PBMCs
The authors' conclusion was: These results suggest that TMC0356 can increase the number of CD8+ T cells and reduce CD28 expression loss in CD8+ T cells of older people. The effect of TMC0356 on immune responses in the elderly may enhance their natural defense mechanisms against pathogenic infections.
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