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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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ABCG5/G8 transporter

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ABCG5 and ABCG8 are two distinct protein subunits that together form the single functional ABCG5/G8 transporter. They act as an obligate heterodimer that transports cholesterol and plant sterols across membranes in liver and intestine.
Graf et al. 2003 J Biol Chem 278(48): 48275-48282
Aiman et al. 2019 Biochem Soc Trans 47(5): 1259-1268

ABCG5 and ABCG8 are each half‑transporters of the ABCG family and cannot function alone at the plasma membrane.
Graf et al. 2003 J Biol Chem 278(48): 48275-48282
Sun et al. 2021 Proc Natl Acad Sci USA 118(34): e2110483118

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References (Sources)

ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion
Graf et al. 2003 J Biol Chem 278(48): 48275-48282
ABCG5/G8: a structural view to pathophysiology of the hepatobiliary cholesterol secretion
Aiman et al. 2019 Biochem Soc Trans 47(5): 1259-1268
Review
Molecular basis of cholesterol efflux via ABCG subfamily transporters
Sun et al. 2021 Proc Natl Acad Sci USA 118(34): e2110483118

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ABCG5/G8 transporter

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