New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD)

AREAS COVERED This review summarizes the use of clinical grading systems and biomarkers in GVHD treatment and highlights pathophysiologic phases of acute GVHD as context for the mechanisms of action and therapeutic targets of various approaches. We reviewed >100 publications and performed a search of ongoing, current clinical trials on the emerging therapeutic targets for prophylaxis and treatment of acute GVHD. Search databases included clinicaltrials.gov and PUBMED. Search terms and keywords included ‘acute graft-versus-host disease,’ ‘GVHD,’ ‘graft versus host,’ ‘treatment.’
EXPERT OPINION Future strategies will employ a risk-adapted therapy using biomarkers, which more accurately predict 6-month non-relapse mortality (NRM). Strategies for high-risk patient…