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Type I invariant NKT (iNKT) cells are rare in the human blood pool, comprising just 0.01-1% of peripheral blood mononuclear cells (PBMCs). They bind and migrate in response to CXCL-16 and develop in the thymus (10).
Both Type I invariant NKT (iNKT) cells and MR1-restricted Mucosal-Associated Invariant T (MAIT) cells can mediate antibody production even in the absence of conventional MHC-II-restricted T cells. This indicates that these cells play a crucial role in the immune response independent of traditional pathways…