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Neurofibromatosis Type 1 (NF1) is an autosomal dominant genetic condition that predisposes individuals to develop plexiform neurofibromas (PN), benign nerve sheath tumors seen in 30–50% of patients with NF1
Acar et al. 2022 Expert Opinion on Investigational Drugs 31: 31-40
Neurofibromatosis type 1 (NF1) is an autosomal dominantly inherited tumor predisposition syndrome with an incidence of one in 3000–4000 individuals with no currently effective therapies.
The NF1 gene on chromosome 17 encodes neurofibromin, which functions as a negative regulator of RAS.
Walker & Upadhyaya 2018 Expert Opin.Ther.Targ. 2…