Bacterial metabolites / Microbial metabolites & Diseases / Disorders

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It regulates virulence and pathogenesis.
Chugh et al. 2025 Trends in Microbiology 33(5): 546

Microbial-derived metabolites (e.g., secondary bile acids, TMAO, Tryptophan & Derivatives) produced in the gut can cross the intestinal epithelial barrier, enter the systemic circulation, and trigger physiological responses, directly and indirectly, affecting the central nervous system and its functions.
Connell et al. 202…

Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential
Roberts et al. 2018 Nat. Med. 24: 1407-1417
Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women
Wang et al. 2019a Eur Heart J 40: 583-594
Indole and tryptophan metabolism: endogenous and dietary routes to Ah Receptor Activation
Hubbard et al. 2015 Drug Metab Dispos 43: 1522-1535
Review
Indoles from commensal bacteria extend healthspan
Sonowal et al. 2017 Proc Natl Acad Sci USA 114: E7506-E7515
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth et al. 2013 Nature Medicine 19: 576-587
Microbially produced imidazole propionate impairs insulin signaling through mTORC1
Koh et al. 2018 Cell 175: 947-961
The exometabolome as a hidden driver of bacterial virulence and pathogenesis
Chugh et al. 2025 Trends in Microbiology 33(5): 546
Review

10/25/2026