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Dysbiosis is often present in Chronic Renal Failure / Chronic Kidney Disease (CKD), reducing the production of beneficial SCFAs. This dysbiosis can worsen the progression of CKD, increasing systemic inflammation and causing the accumulation of uremic toxins that damage kidney function. Studies have shown that interventions to restore a healthy gut microbiome can increase the production of SCFAs and potentially mitigate some of the side effects associated with CKD.
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