Medical Research Finder

Start
Features
Free trial / FAQ

Researchers
Physicians
Pharmacists
Ecotrophologists
Product Managers
in Health Industries

Loading…

© 2026 meRfi®

Medical Research Finder

Legal Notice
Privacy
Terms of Use

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

meRfi® AI Chat

Bacterial Polysaccharide A (PSA) & Regulatory T Cells (Tregs)

Welcome to meRfi Microbiome!

Please register to continue your trial period!

meRfi Microbiome provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.

Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.

Start your free trial and transform your understanding of the gut microbiota today!

Register for a free trial

Navigation

Contents

Bacterial Polysaccharide A (PSA) is zwitterionic, and puriﬁed PSA has been shown to modulate host cytokine levels and induce CD4+ CD25+ Treg that protect against a variety of models of autoimmune inﬂammatory diseases
Mazmanian et al. 2008
Ochoa-Reparaz et al. 2010 Mucosal Immunol. 3: 487-495
Johnson et al. 2018b Glycobiology 28: 50-58
Ramakrishna et al. 2019 Nat. Commun. 10: 2153

For example, polysaccharide A from Bacteroides fragilis can stimulate the differentiation and…

References (Sources)

A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease
Ochoa-Reparaz et al. 2010 Mucosal Immunol. 3: 487-495
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian et al. 2005
Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis
Ramakrishna et al. 2019 Nat. Commun. 10: 2153
Gut biogeography of the bacterial microbiota
Donaldson et al. 2016 Nat. Rev. Microbiol. 14: 20-32
Review
Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms
Dasgupta et al. 2014 Cell Host and Microbe. 15: 413-423
Polysaccharide-experienced effector T cells induce IL-10 in FoxP3+ regulatory T cells to prevent pulmonary inflammation
Johnson et al. 2018b Glycobiology 28: 50-58
Tailoring the homing capacity of human Tregs for directed migration to sites of Th1-inﬂammation or intestinal regions
Hoeppli et al. 2018 Am. J. Transplant. 19: 62-76

AI Chat

7/1/2026

Chat with our artificial intelligence: