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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Aryl Hydrocarbon Receptor (AhR) & T helper 17 cell (Th17)

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The transcription factor aryl hydrocarbon receptor (AHR) is activated by ligands derived from food or intestinal microbiota
Zelante et al. 2013 Immunity 39: 372–385
Moura-Alves et al. 2014 Nature 512(7515): 387-92

Aryl Hydrocarbon Receptor (AhR) is highly expressed already in early stages of T helper 17 cell (Th17) differentiation. However, Aryl Hydrocarbon Receptor (AhR) expression is not essential for Th17 cell differentiation.
Quintana et al. 2008 Nature 453(7191): 65-71
Veldhoen et al. 2008 Nature 453(7191): 1…

References (Sources)

AhR sensing of bacterial pigments regulates antibacterial defence
Moura-Alves et al. 2014 Nature 512(7515): 387-92
Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor
Quintana et al. 2008 Nature 453(7191): 65-71
External inﬂuences on the immune system via activation of the aryl hydrocarbon receptor
Stockinger et al. 2011 Semin. Immunol. 23: 99-105
Review
TH17 cell and epithelial cell crosstalk during inﬂammatory bowel disease and carcinogenesis
Kempski et al. 2017
Review
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
Veldhoen et al. 2008 Nature 453(7191): 106-942
Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via IL-22
Zelante et al. 2013 Immunity 39: 372–385

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Aryl Hydrocarbon Receptor (AhR) & T helper 17 cell (Th17)

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