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Fluorothiazinone is a novel, non-traditional antibacterial drug that inhibits bacterial virulence factors. It inhibits the type III secretion system (T3SS) and thereby disrupts the formation of bacterial flagella in gram-negative bacteria. Its primary effect is thus a reduction in motility and pathogenicity.
Fluorothiazinone is actively being studied for infections caused by multi-resistant gram-negative pathogens, including Pseudomonas aeruginosa.
Its anti-virulence mechanism is particu…