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The FDA and EMA both recognize corticosteroids, including hydrocortisone, as standard therapy for Ulcerative Colitis (UC), mostly indicated in relapse or acute flare scenarios, often via enemas, foams, or suppositories for distal colitis/proctosigmoiditis but it does not hold a specific standalone FDA or EMA approval as an initial or primary agent for UC (1, 2, 3)
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