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STING (Stimulator of interferon genes) dependent antitumor activity correlated with increased activation of dendritic cells (DC) and tumor-antigen specific Cytotoxic T cell (CTL).
Activation of the STING (stimulator of interferon genes) protein by its natural ligand, cyclic guanosine monophosphate–adenosine monophosphate (cGAMP), triggers signaling responses, inducing the release of [type I interferons](brain://LwP7CNdUY06d6pBQBr8NJA/…