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Mutations in tail fiber genes refer to changes in the genes that code for the tail fibers of bacteriophages. The tail fibers of a bacteriophage play a crucial role in the infection process as they are responsible for recognizing and binding to the host receptor. Mutations in these genes can alter the structure of the tail fibers, potentially allowing the bacteriophage to infect a wider range of host bacteria or to bind more effectively to the host receptors. This can increase the bacteriophage's ability to establish and maintain its presence in the gut microbiome.