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Lactobacillus acidophilus L-92 has anti-allergic immunomodulatory effects when administered orally in mice. Microfold cells (M cells) are responsible for the internalization of L-92, triggering immune responses. L-92 binds specifically to uromodulin, a protein found only on M cells among intestinal epithelial cells.
Internalization of Lactobacillus acidophilus L-92 is significantly reduced in uromodulin-deficient (Umod-/-) mice compared to Umod+/+ mice. The binding of L-92 to uromodulin decreases significantly when [surface layer protein A (SlpA)](brain://WcWYhzVpZUGhWttUWGHl5g/SurfaceLayerPr…