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Histone deacetylases (HDACs) are enzymes that remove acetyl groups from histone and non-histone proteins, influencing gene expression and playing roles in many biological and pathological processes, while the Sodium-Coupled Monocarboxylate Transporter 1 (SMCT1) is a membrane transporter that imports butyrate, a natural HDAC inhibitors. Notably, Sodium-Coupled Monocarboxylate Transporter 1 (SMCT1) acts as a [tumor suppressor](brain://WCG0X…