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Malignant brain tumors remain incurable diseases. The high tumor heterogeneity, the strongly tumor-induced immunosuppressive microenvironment, and the low mutation burden make therapy difficult.
Current standard of care includes surgery and radiation, but overall survival remains poor.
Tumor resistance to current standard therapies poses a substantial barrier to cure, but a variety of agents are under investigation that have the ability to overcome resistance-causing mutations
Current advancements in the medical management of brain metastases can be categorized into targeted therapies, methods of overcoming treatment resistance, novel combinations of therapies…