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An analog of humanin, S14G-humanin (HNG), has demonstrated protective effects against various cardiovascular diseases.
It has been found that humanin may promote the activation of Nrf2 , a crucial signaling pathway involved in the regulation of apoptosis, cell differentiation, and proliferation, by inhibiting the expression of Keap1 during myocardial infarction
Humanin also plays an important role in cytoprotection as an anti-apoptosis…