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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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GV-971 & Alzheimer’s Disease (AD)

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GV-971 is a mixture of oligosaccharides to inhibit Alzheimer’s Disease (AD) by manipulating the gut microbiota
Wang et al. 2019x Cell Research 29:787-803

Recently, GV-971 improved Cognitive impairment in a phase III clinical trial in AD in China (unpublished data)
Wang et al. 2019x Cell Research 29:787-803

Consistent with previous reports (Oakley et al. 2006 J. Neurosci. 26: 10129-10140; Kimura & Ohno 2009 Neurobiol. Dis. 33: 229-235; Jawhar et al. 2012 Neurobiol. Aging 33: 196 e129-140; Kanno et al. 2014 Be…

References (Sources)

Hyperphosphorylation of Tau at Ser396 occurs in the much earlier stage than appearance of learning and memory disorders in 5XFAD mice
Kanno et al. 2014 Behav. brain Res. 274: 302-306
Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model
Kimura & Ohno 2009 Neurobiol. Dis. 33: 229-235
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with ﬁve familial Alzheimer’s disease mutations: potential factors in amyloid plaque formation
Oakley et al. 2006 J. Neurosci. 26: 10129-10140
Motor deﬁcits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Abeta aggregation in the 5XFAD mouse model of Alzheimer’s disease
Jawhar et al. 2012 Neurobiol. Aging 33: 196 e129-140
Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinﬂammation to inhibit Alzheimer’s disease progression
Wang et al. 2019x Cell Research 29:787-803

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