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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

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VE303 & Clostridioides difficile infection (CDI) (recurrent)

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Randomized clinical trials (RCTs)

NCT03788434
demonstrates a significant reduction in CDI recurrence among high-risk adults, especially with high-dose VE303 compared to placebo. These findings support ongoing Phase III clinical development (1, 2)

NCT06237452
as of May 2026 the trial is currently recruiting patients.

References

(1) Louie et al. 2023 JAMA 329: 1356
(2) Menon et al. 2025 Nat Med 31(1): 223-234

see also:
Clostridioides difficile infection (CDI) (recurrent) & Drugs/Treatments
[Fecal Microbiota Transplant…

References (Sources)

First microbiome-based drug clears phase III, in clinical trial turnaround
Garber 2020 Nat. Rev. Drug Discov. 19: 655–656
Microbiota-targeted therapies in inflammation resolution
Strati et al. 2022 Semin Immunol 59: 101599
Review
Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection
Menon et al. 2025 Nat Med 31(1): 223-234
Update on microbiota-derived therapies for recurrent Clostridioides difficile infections
Benech et al. 2024 Clinical Microbiology and Infection 30: 462-468
Review
VE303, a Defined Bacterial Consortium, for Prevention of Recurrent Clostridioides difficile Infection A Randomized Clinical Trial
Louie et al. 2023 JAMA 329: 1356

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