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CD4 - CD8 - Regulatory T Cells (Tregs) (DN Tregs) can arise spontaneously (natural Treg) or can be induced in situ
They can suppress alloimmune responses by contact-dependent mechanisms by either inducing Apoptosis or mediating direct cytolysis of effector T cells
CD4 - CD8 - Regulatory T Cells (Tregs) can also act in a contact-independent manner by elaborating soluble immunosuppressive factors, such as TGF- beta and IL-10
These double negative (DN) CD4 - CD8 - Regulatory T Cells (Tregs) are adaptively…