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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Tetrahydrocannabinol (THC) & Ulcerative colitis (UC)

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There is currently no FDA or EMA approval for Tetrahydrocannabinol (THC) as a treatment for ulcerative colitis (UC). While THC and other cannabinoids have been researched for inflammatory bowel diseases, including UC, most guidelines and reviews emphasize that cannabinoid therapies (including THC) have not demonstrated sufficient efficacy or safety to merit regulatory approval for this indication (1, 2, 3).

References:

(1) Buckley et al. 2021 Adv Ther 38(7): 4152-4161
(2) Vinci et al. 2022 Biomedicines 10: 2439
(3) Kafil et al. 2018 Cochrane Database of Systematic Reviews 11: CD012954

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References (Sources)

Cannabinoid Therapeutic Effects in Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Vinci et al. 2022 Biomedicines 10: 2439
Review
Cannabis for the treatment of ulcerative colitis
Kafil et al. 2018 Cochrane Database of Systematic Reviews 11: CD012954
Review
Inflammatory Bowel Disease and Cannabis: A Practical Approach for Clinicians
Buckley et al. 2021 Adv Ther 38(7): 4152-4161
Review

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7/2/2026

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