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The ligands and receptors that allow small-intestinal tuft cells to sense luminal helminths remain unknown. During eukaryotic colonization, pathogen sensing by tuft cells appears to involve an incompletely defined mechanism. Tuft cells express receptors for short-chain fatty acids (including GPR41) and [succinate](brain://api.thebrain.com/wzsofVOsh4ANI-lTZFbXXQ/kSAjnPnIuUS…