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The advent of Biologic agents such as anti-TNF agents (e.g., infliximab, adalimumab, and golimumab) and cytokine inhibitors (e.g., Interleukin-12 (IL-12) antagonists / Interleukin-23 (IL-23) antagonists , ustekinumab) have revolutionized treatment options, particularly for those refractory to conventional medication