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Plasmacytoid DCs (pDCs) activate and differentiate naive B cells in the lamina propria into plasma cells. These plasma cells produce commensal-specific IgA. IgA forms dimeric complexes. These complexes are bound by the polymeric immunoglobulin receptor (pIgR) on the basolateral membrane of IECs. IgA is actively transcytosed into the intestinal lumen as secreted IgA (sIgA) (2, 3)
Dendritic Cells (DCs) - deficient mice produce increased levels of secreted immunoglobulin A (sIgA)/IgA. These mice have a higher quantity of IgA-coate…